| Ab 2021 | 143/194 | CLS 220 d | R1ECLS | Diesel | 5/112 | 18 |
| Ab 2021 | 195/265 | CLS 300 d 4MATIC | R1ECLS | Diesel/Elektro (h) | 5/112 | 18 |
| Ab 2021 | 220/299 | CLS 350 | R1ECLS | Benzin/Elekto (h) | 5/112 | 18 |
| Ab 2021 | 243/330 | CLS 400 d 4MATIC | R1ECLS | Diesel | 5/112 | 18 |
| Ab 2021 | 270/367 | CLS 450 4MATIC | R1ECLS | Benzin/Elekto (h) | 5/112 | 18 |
